Frank, if she/he was a mosaic then wouldn't the androgen insensitivity be likewise distributed among the various cells of her/his body? You'd just end up with an intersexed individual with combined ovarian and testicular tissue and intermediate genitalia (as most intersexed people have).FrankTrollman wrote:No. I mean almost impossible. In biology, almost nothing is completely impossible.Lago PARANOIA wrote: Don't you mean completely impossible?
We aren't chickens, so you can't just graft some cells with male DNA to some cells with female DNA and get functional male and female parts on different parts of the body. Each piece of gonadal tissue develops into functionality at the behest of hormones - hormones that circulate in the blood. So you'd think that even in the case of genetic mosaicism and partial duplication where someone has two sets of gonads, that the hormones would still have a sword fight and one or the other would win and only one (or none) of the gonad sets would actually take hold. And normally, you'd be right.
However, there exist mutations that deny cells androgen receptors, and people who have those mutations develop into pretty sexy looking women even if they are males. And those mutations are governed on a cell by cell basis - like a chicken. So if you had a genetic mosaic which was predominantly female with an androgen receptor knock-out and the other cell line included an exogenous gonad duplication and was itself male, then you would indeed make a large breasted woman with functional uterus who nonetheless had a penis and a set of testicles.
Not going to happen, but it's possible. In Biology, almost everything is possible.
-Username17
Even if the distribution of cells wasn't random, you wouldn't end up with functional 'double set' because male and female organs develop from the same tissues. He/she couldn't have both testicles and ovaries.
If the androgen insensitivity existed in all cells, then the Wolffian system would be re-absorbed as normal and the person wold be effectively female (aside from reproduction).
Sorry to burst your bubbles, dickgirl lovers out there.